Signaling
Transcription factors, cytokines, and receptors that govern the myelocyte stage: what switches the cell on, what pushes it forward, what arrests it.
Without G-CSF, marrow granulopoietic precursors fall by 50 percent and blood neutrophils to 20 to 30 percent of normal.
G-CSF drives release indirectly; downregulation of stromal SDF-1 is a candidate signal.
CXCL12 on CXCR4 retains neutrophils in marrow; CXCR2 opposes it; CXCR4 dominates.
C/EBP epsilon is required for the promyelocyte to myelocyte transition.
C/EBP epsilon rises as granulocytic differentiation proceeds.
Review of how cancer rewires emergency granulopoiesis, including expansion of immature neutrophils.
A Znf711-Phf8 transcriptional complex is required for neutrophil development.
Lipid mediators made by erythroblasts, the marrow neighbors of the granulocytic series, program neutrophil development.